Don't bother asking to see their degrees.
This unnamed scientist has been kidnapping preteens and changing them into hulking brutes via some pretty fantastical brain surgery. He of course gets his ass fatally handed to him by the Red Panther but not before he goes on about producing a new super race and as always I have to question your devotion to science if you think that your physical alterations to these kids are going to be passed on. Who are you, Lamarck? You're going to be performing brain operations on babies all day every day. (Jungle Comics 009, 1940)
Von Blumb is a scientist who is saved from death and treated well by Camilla in her Lost Empire, then heads off into the wilderness to further his research. When he doesn't return after a few weeks, Camilla and Sir Champion head out to check on him and he repays their consideration by capturing them and subjecting them to his reducing serum and adding them to his collection of unwilling subjects. Long story short, they get loose, defeat his pet spider in gladiatorial combat and he gets squashed by a rock. (Jungle Comics 012, 1940)
Von Lohfer is a scientist with a grudge against John D Rockefeller stand-in J B Rockland, who called him a fake and ruined his life. But if Rockland was claiming that von Lohfer was unable to mind control a bunch of cops into doing his bidding he was dead wrong, because that's just what he does until he is ultimately stopped by Quicksilver. (National Comics 005, 1940)
Dr Morbidd has a great name and a really remarkable facial deformity, and he's been using science to raise people from the dead to do his bidding. This is all solid stuff but it doesn't amount to much actual super-villainy. There's some allusion to Morbidd's science zombies being sent out to do murders but the major thing he seems to be interested in is being a real creep to this one young woman he has captured. It would be quite narratively satisfying if he met his end at the hands of his own creations, but sadly he gets his head blown clean off when Merlin the Magician reflects his own death ray beam back at him. (National Comics 005, 1940)
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