Science for all! Whether they want it or not!
Doctor Ivan has been pursuing a scheme in which he is systematically taking out insurance policies on everyone he knows and then having them murdered, and he is extremely smug about it. Now, I'm no expert in insurance fraud, but I have to say that I am certain that it requires a bit more subtlety than that, even if you're doing it as a one-off. Forget the fact that the Flame shows up after the third murder; I would expect some raised eyebrows down at the insurance company after the second. (The Flame 003, 1940)
Dr Gung is an old associate of magical arch-criminal Elena, and is the one who saves her from execution after the Karoly Gore affair by means of some death-simulating drugs.
Gung's main line of inquiry is the use of his signature ray to destroy men's minds and turn them into mindless robot soldiers, something that works perfectly well on regular guys sourced from the nearby populace but when tried on Mr Mystic goes badly enough that Dr Gung ends up shrunk to a few inches tall and then blown to smithereens along with his entire mansion. (The Spirit Section, 23 June 1940)
Ghantse is one of those mad scientists who talk a lot about their grand plans but don't actually get a chance to put them in motion, so it's a real mystery whether he actually would have been able to fuse several human brains together into a single entity who would "know all" like he claimed or not, but he sure was willing to try. Along the way, he made two major mistakes: 1) targeting Mr Mystic for brain extraction and 2) somehow ending up with the Shadowman, the literal embodiment of death, on his payroll, the latter being compounded by the fact that the Shadowman hates Ghantse's guts, and so not only releases Mr Mystic from his chemically-induced paralysis before Ghantse can extract his brain but also blows Ghantse's entire base to kingdom come. (The Spirit Section, 22 September, 1940)
Doctor Zorn, an eccentric roboticist living on Puerto Rico, is possibly the world record holder for escalation, as he manages to go from an argument about a late loan payment to unleashing his voice-controlled super robot (aka the Monster) to activating his lab's self-destruct mechanism in the space of about half an hour.
Given that this is what he started shouting immediately after showing off his robot to a young woman, I do suspect that Doctor Zorn was primed for this kind of thing and was just looking for an excuse, like a man who has just bought a katana standing in his kitchen. (Thrilling Comics 005, 1940)
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